Procarbazine from wikipedia, the free encyclopedia jump to navigation jump to search. The drug is metabolized and activated in the liver. Phase i trial of procarbazine as a 5day continuous. Myelosuppression was moderate though occasionally delayed, and nausea and vomiting were mild. Procarbazine side effects, dosage, interactions drugs everyday health search.
Procarbazine is an antineoplastic chemotherapy drug for the treatment of hodgkins lymphoma and certain brain cancers such as glioblastoma multiforme. Procarbazine should therefore be used only against malignant disease by clinicians experienced in its use and cognizant of potential adverse effects. Patient information include the front and back copy of the patients insurance card. Seven children with previously treated brain tumors were enrolled in a phase i trial of 5day continuousinfusion procarbazine at 360, 480, and 638 mgm2day. By continuing to use our website, you are agreeing to our use of cookies. Procarbazine may lower your bodys resistance and there is a chance you might get the infection the immunization is meant to prevent. Combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone in previously treated patients with hodgkins disease. Listing a study does not mean it has been evaluated by the u. The antineoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. In most such combination chemotherapy regimens currently in use eg.
The anticancer activity of this agent results from oxidation to azoprocarbazine and additional noxidation to a mixture of azoxy isomers. Procarbazine may cause fetal harm if administered to a pregnant female. Peak csf levels are achieved 3090 minutes after oral administration. Procarbazine is an orally administered alkylating agent used in combination with other antineoplastic agents in the therapy of hodgkins disease and malignant melanoma. Combination chemotherapy with nitrogen mustard, vincristine. Cancer studies in experimental animals exposure to procarbazine hydrochloride by intraperitoneal injec. Procarbazine, lomustine and vincristine pcv in recurrent glioblastoma gbm retrospective single institution study evaluating survival and response rates november 2014 doi. Procarbazine should be taken whole and not crushed, cut, or dissolved. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair enzymes and sensitizes idh mutant cells to alkylating agents. The following doses are for administration of the drug as a single agent. In addition, other persons living in your household should not take or should not have recently taken oral polio vaccine since there is. Each capsule also contains cornstarch, mannitol and talc.
Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. However, some foods may interact with procarbazine. Enter synonyms, trade names or additional information found in section 1. Matulane patient assistance program patient assistance. Procarbazine and lomustine in recurrent glioblastoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair enzymes and. Along with their needed effects, medicines like procarbazine can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. Pdf available procarbazine, lomustine and vincristine pcv in recurrent glioblastoma gbm retrospective single institution study evaluating survival and response rates november 2014. Procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Apr 10, 2018 procarbazine can be taken with or without food, but at the same time each day. The names procarbazine and procarbazine hydrochloride are used interchangeably in published studies. Ibenzmethyzin in the management of late hodgkins disease, in report of the proceedings of a symposium. Procarbazine therapy has been associated with serum enzyme elevations during therapy and with rare cases of idiosyncratic, clinically apparent acute liver injury.
Combination chemotherapy with four drugsnitrogen mustard, vincristine, procarbazine and prednisonewas used in 27 previously treated patients with advanced progressive hodgkins disease. Furthermore, the differential mutagenic effects obtained using s. Please see the drug and food interactions section for more details. Patient information include the front and back copy of. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the transmethylation of methionine into transfer rna trna, thereby preventing protein synthesis and consequently dna and rna synthesis. Procarbazine in the management of late hodgkins disease. Ris zotero endnote bibtex medlars procite refworks reference manager mendeley. This page was last edited on 8 january 2016, at 21. Methotrexate 35 gm 2 was given on an identical dosing schedule days 1 and 15 as described above. Procarbazine in treating patients with recurrent brain tumor.
This article is from mediterranean journal of hematology and infectious diseases, volume 4. File scanned at 300 ppi monochrome, 24bit color using scandall pro 1. Oncometabolite d2hydroxyglutarate inhibits alkbh dna. The oxidation of procarbazine, catalyzed by horseradish peroxidase, prostaglandin synthetase ram seminal vesicle rsv microsomes or rat hepatic microsomal. In vitro activation of procarbazine to sytotoxic species. Matulane patient assistance program patient assistance programs. Procarbazine may also be used for purposes not listed in this medication guide. Tmic is funded by genome alberta, genome british columbia, and genome canada, a notforprofit. Procarbazine and lomustine in recurrent glioblastoma.
Interactions between procarbazine oral and avoidhigh. Nov 09, 2018 procarbazine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Surfduedlqh cancer care ontario cancer care ontario. Procarbazine is a chemotherapy medication used for the treatment of hodgkins lymphoma and brain cancers. Article pdf available in european journal of cancer 40. Thirtyeight patients with advanced hodgkins disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone cvpp. Oehha is subject to the california public records act and other laws that require the release of certain information upon request. Phase i trial of procarbazine as a 5day continuous infusion. Intracellular oxidation of glutathione in l5178y lymphoma.
Twentyeight patients 74% achieved complete remission. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. These isomers were synthesized and purified, and their cytotoxic effects against leukemia. Dec 10, 2014 procarbazine quickly equilibrates between the blood and cerebrospinal fluid csf. It also inhibits mao thus increasing the effects of sympathomimetics, tcas, and tyramine. Aug 20, 2003 procarbazine in treating patients with recurrent brain tumor the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Pdf link pdf citation stanley lowenbraun, vincent t. Patients in the methotrexate, procarbazine, vincristine, and cytarabine group received three 28day cycles of chemotherapy. It has been used in the treatment of many cancers, but its main use is in the treatment of hodgkins lymphoma and brain tumors and, to a lesser extent, nonhodgkins lymphoma and primary central nervous system lymphoma. A demonstration of the in vitro bacterial mutagenicity of. Procarbazine is rapidly metabolised, the primary circulating metabolite is the azo derivative while the major urinary metabolite has been shown to be nisopropyl. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Procarbazine is a 1,2disubstituted hydrazine derivative that acts as a methylating agent in the treatment of hodgkins disease, leukemias, lymphomas, and brain tumors. For hodgkins it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. Page 1 procarbazine oral chemotherapy education name of your medication generic name procarbazine proh kar buh zeen brand name matulane ma choo layn approved uses procarbazine is used to treat hodgkins disease. Pdf procarbazine, lomustine and vincristine pcv in. Reappraisal of the use of procarbazine in the treatment of. Methylprednisolone was given on days 15 and filgrastim 5. Abstractpatients with hodgkin lymphoma treated with dnabreaking. For hodgkins it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and.
Files are available under licenses specified on their description page. Amethopterin, amethopterine, antifolin, methotrexat, methylaminopterin, methylaminopterium, ledertrexate. Procarbazine is usually administered concomitantly with other appropriate cytostatic drugs in repeated four to sixweekly cycles. Intracellular oxidation of glutathione in l5178y lymphoma cells by procarbazine and diamide.
This file is licensed under the creative commons attributionshare alike 4. Procarbazine hcl is a nonclassical oral alkylating anticancer agent that was first synthesized in the late 1950s. Webmd provides information about interactions between procarbazine oral and avoidhightyraminefoods. Vincristine 14 mgm 2 suggested dose capping at 28 mg was given on days 1 and 15. Procarbazine and lomustine in recurrent glioblastoma full. If you submit this form, please be aware that your name and email may be provided to third parties. It is a member of a group of medicines called alkylating agents. S0182 hcpcs code procarbazine, oral hcpcs registry. Nov 29, 2012 procarbazine and lomustine in recurrent glioblastoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metabolic activation. There are case reports of fetal malformations in the offspring of pregnant women exposed to procarbazine as part of a combination chemotherapy regimen. Procarbazine is given with other cancer medicines to treat hodgkins disease a type of blood cancer. Oncometabolite d2hydroxyglutarate inhibits alkbh dna repair. Ibenzmethyzin in the management of late hodgkins disease, in report of the proceedings of a symposium, downing college, cambridge, june 22, 1965. Procarbazine is in a class of medications called alkylating agents.
The metabolism of procarbazine was studied using spintrapping techniques. Find patient medical information for procarbazine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Matulane procarbazine hydrochloride, a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Procarbazine carcinogenicity in methotrexatetreated or. Procarbazine hydrochloride pcz, a chemotherapeutic agent used extensively to treat hodgkins disease and other tumors,induces leukemia, lymphoma, ma we use cookies to enhance your experience on our website. Procarbazine side effects, dosage, interactions drugs. All structured data from the file and property namespaces is available under the creative commons cc0 license. Procarbazine can be taken with or without food, but at the same time each day. The drug offers some benefits for patients with lymphomas of other than hodgkins type and small and large cell carcinomas of lung, but there has been no documented enlargement of the role of procarbazine beyond these applications during the past 5 years. Procarbazine 100 mgm 2 per day was given on days 17. Procarbazine and procarbazine hydrochloride are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. It works by slowing or stopping the growth of cancer cells in your body. Longterm survival of patients with hodgkins disease.